Cancer: How THIS common sugar supercharges the immune system against cancer |
Ever heard of sweet revenge? Well, you might be against it, but your body is actually doing it. Yes, that’s right. There is a sweet twist in how your body is fighting off cancer. A new study by researchers at the Van Andel Institute found that glucose boosts cancer-fighting properties. The findings of the study are published in Cell Metabolism. Sweet twist
The new study found that glucose might be providing more than a sugar rush to cancer and infection-fighting T cells. The study uncovered that glucose, which is an essential cellular fuel that powers the immune cells, also aids in T cells’ internal communication and boosts their cancer-fighting properties. These findings may help to optimize T cells’ ability to combat cancer and other diseases.
(Pic courtesy: iStock)
“Immune cells are highly influenced by their environment. We knew that T cells need access to glucose to function, but we didn’t know exactly why. It was previously thought that T cells mainly break down glucose for energy, but our new work shows that T cells use glucose as a building block for other molecules that are necessary to support T cells’ anti-cancer properties,” Joseph Longo, Ph.D., the study’s first author and a postdoctoral fellow in the lab of Russell Jones, Ph.D, said in a statement. Building blocks for cancer defense
(Pic courtesy: iStock)
The study found that T cells use a lot of glucose to make large molecules called the glycosphingolipids (GSLs). These are sugar-fat compounds that help them grow and produce proteins that T cells use to combat cancer.The GSLs help to form fat-rich structures on T cell surfaces known as lipid rafts. These rafts bring together cell signaling proteins that instruct the T cell to kill cancer cells. So when there is no GSLs, these signals become weaker, making T cells less effective at destroying tumors.
“Both T cells and cancer cells leverage different nutrients to support varying aspects of their function. The more we know about these different fuel sources, the better we can support T cells’ innate cancer-fighting abilities while also developing ways to possibly make cancer cells more vulnerable to immune attack,” Jones said.Glucose, which was only considered a basic energy source, is now a critical factor in how immune cells organize and communicate to carry out their cancer-killing mission, thanks to the new research.
var _mfq = window._mfq || [];
_mfq.push([“setVariable”, “toi_titan”, window.location.href]);
!(function(f, b, e, v, n, t, s) {
function loadFBEvents(isFBCampaignActive) {
if (!isFBCampaignActive) {
return;
}
(function(f, b, e, v, n, t, s) {
if (f.fbq) return;
n = f.fbq = function() {
n.callMethod ? n.callMethod(…arguments) : n.queue.push(arguments);
};
if (!f._fbq) f._fbq = n;
n.push = n;
n.loaded = !0;
n.version = ‘2.0’;
n.queue = [];
t = b.createElement(e);
t.async = !0;
t.defer = !0;
t.src = v;
s = b.getElementsByTagName(e)[0];
s.parentNode.insertBefore(t, s);
})(f, b, e, ‘https://connect.facebook.net/en_US/fbevents.js’, n, t, s);
fbq(‘init’, ‘593671331875494’);
fbq(‘track’, ‘PageView’);
};
function loadGtagEvents(isGoogleCampaignActive) {
if (!isGoogleCampaignActive) {
return;
}
var id = document.getElementById(‘toi-plus-google-campaign’);
if (id) {
return;
}
(function(f, b, e, v, n, t, s) {
t = b.createElement(e);
t.async = !0;
t.defer = !0;
t.src = v;
t.id = ‘toi-plus-google-campaign’;
s = b.getElementsByTagName(e)[0];
s.parentNode.insertBefore(t, s);
})(f, b, e, ‘https://www.googletagmanager.com/gtag/js?id=AW-877820074’, n, t, s);
};
function loadSurvicateJs(allowedSurvicateSections = []){
const section = window.location.pathname.split(‘/’)[1]
const isHomePageAllowed = window.location.pathname === ‘/’ && allowedSurvicateSections.includes(‘homepage’)
const ifAllowedOnAllPages = allowedSurvicateSections && allowedSurvicateSections.includes(‘all’);
if(allowedSurvicateSections.includes(section) || isHomePageAllowed || ifAllowedOnAllPages){
(function(w) {
function setAttributes() {
var prime_user_status = window.isPrime ? ‘paid’ : ‘free’ ;
var geoLocation = window?.geoinfo?.CountryCode ? window?.geoinfo?.CountryCode : ‘IN’ ;
w._sva.setVisitorTraits({
toi_user_subscription_status : prime_user_status,
toi_user_geolocation : geoLocation
});
}
if (w._sva && w._sva.setVisitorTraits) {
setAttributes();
} else {
w.addEventListener(“SurvicateReady”, setAttributes);
}
var s = document.createElement(‘script’);
s.src=”https://survey.survicate.com/workspaces/0be6ae9845d14a7c8ff08a7a00bd9b21/web_surveys.js”;
s.async = true;
var e = document.getElementsByTagName(‘script’)[0];
e.parentNode.insertBefore(s, e);
})(window);
}
}
window.TimesApps = window.TimesApps || {};
var TimesApps = window.TimesApps;
TimesApps.toiPlusEvents = function(config) {
var isConfigAvailable = “toiplus_site_settings” in f && “isFBCampaignActive” in f.toiplus_site_settings && “isGoogleCampaignActive” in f.toiplus_site_settings;
var isPrimeUser = window.isPrime;
var isPrimeUserLayout = window.isPrimeUserLayout;
if (isConfigAvailable && !isPrimeUser) {
loadGtagEvents(f.toiplus_site_settings.isGoogleCampaignActive);
loadFBEvents(f.toiplus_site_settings.isFBCampaignActive);
loadSurvicateJs(f.toiplus_site_settings.allowedSurvicateSections);
} else {
var JarvisUrl=”https://jarvis.indiatimes.com/v1/feeds/toi_plus/site_settings/643526e21443833f0c454615?db_env=published”;
window.getFromClient(JarvisUrl, function(config){
if (config) {
const allowedSectionSuricate = (isPrimeUserLayout) ? config?.allowedSurvicatePrimeSections : config?.allowedSurvicateSections
loadGtagEvents(config?.isGoogleCampaignActive);
loadFBEvents(config?.isFBCampaignActive);
loadSurvicateJs(allowedSectionSuricate);
}
})
}
};
})(
window,
document,
‘script’,
);
Source link
